Resources Medication Resource Centre Nozinan (methotrimeprazine)

Nozinan (methotrimeprazine)

Nozinan (methotrimeprazine)
Brand name: Nozinan®
Active ingredient name: Methotrimeprazine
Type of drug: Typical antipsychotic
Form: Injection, oral tablets
Brand name available in Canada from: Erfa Canada Inc.
Generic: Yes: Apo-Methoprazine (Apotex Inc.); Novo Meprazine Tab (Novopharm Ltd.); PMS-Methotrimeprazine (Pharmascience Inc.)
Listed on Ontario formulary: Yes

What is Nozinan used for?
Nozinan is used to treat symptoms of schizophrenia and other psychotic illnesses.  It may also be used to treat bipolar disorder, or for conditions associated with anxiety. Nozinan may be used to treat other conditions as well. Discuss with your doctor why you are using Nozinan.
How should I take Nozinan?
Nozinan can be taken with or without food.  It can be taken once per day, however it is most often given twice or three times daily.
How much Nozinan should I take?
Nozinan is available in injectable form in a 25 mg/mL concentration. The generic form of Nozinan is also available in 2, 5, 25, and 50 mg tablets.
The oral starting dose of Nozinan for schizophrenia and other psychotic illnesses is 50-75 mg per day.  The dose is increased up to a maximum of 1000 mg per day depending on response.  Discuss your individual dose with your doctor.
What are the common side effects seen with Nozinan? 

Side effects of Nozinan may include:
  • Abnormal movements (extrapyramidal symptoms)
  • Changes in monthly menstrual cycle (amenorrhea)
  • Decreased sexual interest and/or function
  • Swelling of breasts and milk production in males and females
  • Drowsiness
  • Dry mouth
  • Nausea
  • Headache
  • Weight changes
  • Blurred vision

What are rare, but potentially serious side effects seen with Nozinan?

  • Decreased white blood cell count (agranulocytosis)
  • Neuroleptic Malignant Syndrome (NMS)
  • Anaphylactic reaction (severe allergy)
  • Torsades de Pointes (a serious heart arrhthymia)

Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics.  Most deaths appear to be either cardiovascular or infectious.  Nozinan is not approved for the treatment of dementia-related psychosis.  Some individuals with dementia may however be treated with this medication. Discuss the potential risks and benefits of this medication with your doctor for this indication.
What medications interact with Nozinan?
Tell all your doctors, pharmacists, and dentist that you are taking Nozinan. You should also tell your doctor or pharmacist if you are taking any other medications, including those obtained without a prescription and herbal and vitamin products.
The following types of medication may interact with Nozinan:

  • Certain medications for  allergies (e.g., Benadryl [diphenhydramine])
  • Certain medications for sleep (e.g., lorazepam, zopiclone)
  • Certain medications for pain (e.g., fentanyl)
Avoid drinking alcohol or using illegal drugs while taking Nozinan.