Resources Medication Resource Centre Zyprexa IntraMuscular (olanzapine tartrate)

Zyprexa IntraMuscular (olanzapine tartrate)

Zyprexa IntraMuscular (olanzapine tartrate)
Brand name: Zyprexa® IntraMuscular
Active ingredient name: Olanzapine tartrate
Type of drug: Atypical antipsychotic
Available in Canada from: Eli Lilly Canada Inc.
Form: Injection
Generic: No
Listed on Ontario formulary: No

Note: Zyprexa® IntraMuscular is also available in tablet form as Zyprexa® and Zyprexa® Zydis®.

What is Zyprexa IntraMuscular used for?

Zyprexa intramuscular injection is a short-acting injectable antipsychotic medication. Although it is an injection it is not a depot or long-acting injection. It is used most often in a hospital setting if an individual needs medicine quickly to help them calm down. This medication is not used long-term to control the symptoms of schizophrenia or other psychotic illnesses. 
How much Zyprexa IntraMuscular should I take?
Zyprexa IntraMuscular is available as a single-use vial containing 10 mg of olanzapine.
Your doctor will decide on the best dose for you based on your needs. Most people need only one dose, but your doctor may give you additional doses as needed. You will receive no more than three injections in a 24-hour period.  

What are the common side effects seen with Zyprexa IntraMuscular? 
The most common side effects of Zyprexa IntraMuscular include:

  • Drowsiness
  • Dizziness
  • Pain at the site of the injection
  • A feeling of restlessness (akathisia)

What are rare, but potentially serious side effects seen with Zyprexa?

  • Anaphylactic reaction (severe allergy)
  • Neuroleptic malignant syndrome (NMS)
Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics. Most deaths appear to be either cardiovascular or infectious. Zyprexa Intramsucular is not approved for the treatment of dementia-related psychosis. Some individuals with dementia may however be treated with this medication. Discuss the potential risks and benefits of this medication with your doctor for this indication.
What medications interact with Zyprexa IntraMuscular?
Zyprexa Intramuscular is for short-term use; hence the risk of drug interactions is reduced. The most clinically significant interaction with this medication is intramuscular lorazepam. These two medications should not be given at the same time. If a person needs lorazepam in addition to Zyprexa Intramuscular it should be given as an oral tablet.