Haldol (haloperidol)

Haldol (haloperidol)
Brand name: Haldol®
Active ingredient name: Haloperidol
Type of drug: Typical antipsychotic
Form: Oral tablets, intramuscular injection (short-acting and long-acting depot)
Brand name available in Canada from: Not available in Canada
Generic: Yes: Apo-Haloperidol Liq, Apo-Haloperidol Tab, Apo-Haloperidol LA Injectable (Apotex Inc.); Haloperidol Inj, Haloperidol LA (Sandoz Canada Inc.); Haloperidol Injection, Haloperidol-LA Omega (Omega Laboratories Ltd.); Novo-Peridol Tab (Novopharm Ltd.); PMS-Haloperidol Soln, Haloperidol-LA (Pharmascience Inc.)
Listed on Ontario formulary: Yes


How much Haldol should I take?
Haldol is available in 1, 2, 5, 10, and 20 mg tablets. Haldol LA is available in 50 and 100 mg/mL vials.
The usual dose of oral Haldol is 4-20 mg daily. Haldol can be taken once daily, however some doctors like to give it 2 to 3 times daily. Your doctor may prescribe doses higher than this range depending on your clinical situation.  Discuss your individual dose with your doctor.
 
If you are receiving long-acting haloperidol injections, you will probably receive injections every 2-4 weeks. Some people may need more frequent injections compared to others. The usual dose range for the depot injection of Haldol is 50-200 mg every 2-4 weeks.

What are the common side effects seen with Haldol?
Side effects of Haldol may include:
  • Abnormal movements (extrapyramidal symptoms)
  • Muscle spasms (dystonia)
  • Changes in monthly menstrual cycle (amenorrhea)
  • Decreased sexual interest and/or function
  • Swelling of breasts and milk production in males and females
  • Dizziness
  • Drowsiness
  • Nausea
  • Loss of appetite
  • Headache
  • Dry mouth
  • Blurred vision
  • Insomnia
What are rare but potentially serious adverse effects with Haldol?
  • Decrease in white blood cell count (aganulocytosis)
  • Neuroleptic Malignant Syndrome (NMS)
  • Sudden cardiac death (heart attack)
  • Torsades de pointes (serious heart arrhythmia)
  • Seizures
In addition to the above physical side effects Haldol has potential mood side effects also. In some individuals Haldol may cause low mood or depression. Some individuals may also feel unhappy, dissatisfied, indifferent and restless. Haldol has also caused confusion and symptoms of memory loss in some individuals. Finally, some individuals have developed anxiety symptoms while taking Haldol.
 
Warnings/Precautions
Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics. Most deaths appear to be either cardiovascular or infectious. Haldol is not approved for the treatment of dementia-related psychosis. Some individuals with dementia may however be treated with this medication. Discuss the potential risks and benefits of this medication with your doctor for this indication.

What medications interact with Haldol?
Tell all your doctors, pharmacists, and dentist that you are taking Haldol. You should also tell your doctor or pharmacist if you are taking any other medications, including those obtained without a prescription and herbal and vitamin products.
 
The following medications and types of medications might interact with Haldol:

  • Bromocriptine
  • Certain medications for allergies (e.g., Benadryl [diphenhydramine])
  • Certain medications for sleep (e.g., lorazepam, zopiclone)
  • Certain medications for pain (e.g., fentanyl)
  • Antiparkinson medications

Avoid drinking alcohol or using illegal drugs while taking Haldol.

Share